Ahead of working with this medication, Ladies of childbearing age really should talk to their medical doctor(s) in regards to the pitfalls and Positive aspects. Convey to your medical professional Should you be Expecting or Consider you might be pregnant. Throughout pregnancy, this medication is just not recommended. It may well a little boost the hazard of start defects if utilized throughout the to start with two months of pregnancy. Also, employing it for years or in substantial doses near the expected delivery day might hurt the unborn newborn.
It can be mysterious if this medication passes into breast milk. However, it may have unwanted results on a nursing infant. Talk to your medical professional before breastfeeding.
Position the combination in a very container for instance a sealed plastic bag and throw it away while in the home trash. It's also possible to observe your condition or neighborhood rules on how to safely and securely toss absent Promethazine Hydrochloride and Codeine Phosphate Oral Answer.
The narcotic antagonist, naloxone hydrochloride, might be administered when substantial respiratory depression occurs with promethazine and codeine; any depressant results of promethazine are certainly not reversed with naloxone. Diazepam can be applied to manage convulsions. Avoid analeptics, which may result in convulsions. Acidosis and electrolyte losses must be corrected. A rise in temperature or pulmonary problems may possibly sign the necessity for establishment of antibiotic therapy.
When employed for an extended time, this medication may not perform likewise and will involve distinct dosing. Talk to your medical professional if this medication stops Doing the job effectively.
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric people fewer than six years of age.
In animal copy experiments, codeine administered by the oral route to pregnant rats in the period of organogenesis elevated resorptions and reduced fetal weights in a dose roughly twenty five moments the utmost advised human dose (MRHD) during Promethazine codeine syrup the existence of maternal toxicity (see Knowledge).
Do not flush drugs down the bathroom or pour them right into a drain Unless of course instructed to take action. Thoroughly discard this product when it's expired or now not desired. Talk to your pharmacist or nearby waste disposal business.
Just before having this medication, explain to your doctor or pharmacist In case you are allergic to any of its components; or to opioid pain relievers (which include morphine); or When you've got another allergy symptoms.
Usually do not rise up or sit up promptly, particularly when you might be an older affected person. This decreases the risk of dizzy or fainting spells. Liquor may perhaps interfere Together with the result of the medication. Stay away from alcoholic beverages.
Critical, lifestyle-threatening, or lethal respiratory melancholy has long been reported with the usage of opioids, together with codeine, on the list of active substances in Promethazine HCl and Codeine Phosphate Oral Option. Codeine produces dose-associated respiratory despair by directly acting to the Mind stem respiratory Centre that controls respiratory rhythm and could develop irregular and periodic respiration. Codeine is issue to variability in metabolism primarily based upon CYP2D6 genotype, which can result in an increased exposure to your Energetic metabolite morphine [see Warnings and Safeguards (5.3)]. Promethazine exerts a depressant impact on the respiratory Heart that's impartial of and additive to that of other respiratory depressants, which includes codeine [see Warnings and Safety measures (5.
Should you have ache, there is a medical purpose to get agony medication. Your care staff will inform you how much medication to get. In case your treatment crew wants you to halt the medication, the dose will probably be bit by bit decreased after some time to prevent any Unwanted side effects.
Codeine is understood to get significantly excreted by the kidney, and the risk of adverse reactions to this drug might be higher in patients with impaired renal perform.
INDICATIONS AND Use Promethazine HCl and Codeine Phosphate Oral Alternative is a combination of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated to the short-term relief of cough and upper respiratory signs associated with allergy or the widespread chilly in sufferers 18 many years of age and older. (one)